Electroacupuncture Potentiates the Antiallodynic Effect of Intrathecal Neostigmine in a Rat Model of Neuropathic Pain
J Physiol Sci Vol.58, No.5 pp.357-360
Abstract: This study was performed to examine whether electroacupuncture potentiates the neostigmine-induced antiallodynia in neuropathic pain rats. Although intrathecal neostigmine (0.05, 0.1, and 0.3 µg) dose-dependently relieved cold allodynia, 0.3 µg neostigmine caused side effects. The coapplication of 0.1 µg neostigmine and electroacupuncture, however, produced potent antiallodynia, which was parallel to the effect of 0.3 µg neostigmine, without side effects. These results indicate that electroacupuncture can enhance the antiallodynic action of intrathecal neostigmine.
Department of East-West Medicine, Graduate School, Kyung Hee University, Seoul, South Korea. mbi@khu.ac.kr
Copyright© 2007 by The Physiological Society of Japan