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Repeated Exposures to Hyperbaric Air Suppress Neurite Outgrowth in PC12 Cells

J Physiol Sci Vol.57, No.5 pp.321-325
Tetsuro Isada, Munetaka Hirose, Eri Murata, Yoko Okayama, Mayumi Takatori, Mayumi Tani, Keita Fukazawa, Masashi Hirata, Satoshi Taniguchi, Kenji Shigemi, Yoshifumi Tanaka
Abstract: Hyperbaric exposure induces lesions of the CNS in scuba divers. Repeated exposures to hyperbaric air at 0.5 MPa for 30 min with short intervals suppressed NGF-stimulated neurite outgrowth, concomitant with a decrease in the protein expression of ERK in PC12 cells. Hyperbaric exposure most likely causes direct lesions of neural cells.

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Department of Anesthesiology and Reanimatology, Faculty of Medical Sciences, Fukui University, Eiheijicho, Yoshidagun, Fukui, 910-1193 Japan. hirosem@u-fukui.ac.jp
Copyright© 2007 by The Physiological Society of Japan