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No Association between Coding Polymorphism within Exon 4 of the Human Surfactant Protein B Gene and Pulmonary Function in Healthy Men

J Physiol Sci Vol.57, No.3 pp.199-202
Stuart M. Raleigh, Benjamin M. Davies, David Cleal, William J. Ribbans
Abstract: The coding polymorphism (rs1130866) within the surfactant protein B gene is known to associate with certain respiratory abnormalities. We investigated, using spirometry and fluorescence-based PCR, whether this variant influenced pulmonary function in healthy, nonsmoking men. We found no association of pulmonary function with genotype at the rs1130866 locus.

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The Biomedical Research Group, Division of Health and Life Sciences, The University of Northampton, NN2 7AL, UK. stuart.raleigh@northampton.ac.uk