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Hyperoxia Attenuates Endothelial-Mediated Vasodilation in the Human Skin

J Physiol Sci Vol.57, No.1 pp.81-84
Fumio Yamazaki
Abstract: The influence of hyperoxia on the cutaneous vasodilator responses to iontophoretic applications of acetylcholine (ACh) and sodium nitroprusside (SNP) was examined in healthy subjects. The breathing of 100% O2 decreased (P < 0.05) the vasodilator response to Ach, but not to SNP, suggesting that hyperoxia attenuates endothelial-mediated vasodilation of the human skin.

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Department of Clinical Pathophysiology, School of Health Sciences, University of Occupational and Environmental Health, Kitakyushu, 807-8555 Japan. yamazaki@health.uoeh-u.ac.jp
Copyright© 2007 by The Physiological Society of Japan