1. Archive
  2. Vol.56, No.5

Browse Article

Article Views

Article Tools

Dysfunction of Paracellin-1 by Dephosphorylation in Dahl Salt-Sensitive Hypertensive Rats

J Physiol Sci Vol.56, No.5 pp.379-383
Akira Ikari, Satomi Matsumoto, Hitoshi Harada, Kuniaki Takagi, Masakuni Degawa, Tadanobu Takahashi, Junko Sugatani, Masao Miwa
Abstract: A high-salt diet reduced the levels of renal cAMP content and serine-phosphorylated paracellin-1 in Dahl salt-sensitive hypertensive rats. In MDCK cells expressing paracellin-1, protein kinase A inhibitor reduced the serine-phosphorylated paracellin-1 and transepithelial Mg2+ transport, suggesting that a dephosphorylation of paracellin-1 induces the reduction of Mg2+ reabsorption in salt-sensitive hypertension.

[Full Text (PDF)]

Department of Pharmaco-Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka 422-8526, Japan. ikari@u-shizuoka-ken.ac.jp
Copyright© 2007 by The Physiological Society of Japan