Does Higher Red Blood Cell (RBC) Lactate Transporter Activity Explain Impaired RBC Deformability in Sickle Cell Trait?
Jpn J Physiol Vol.55, No.6 pp.385-387
Abstract: Lactate and H+ are suggested to promote the sickling process in red blood cells (RBCs) containing hemoglobin S. We demonstrated greater activity of the RBC monocarboxylate cotransporter MCT-1, lower RBC deformability and impaired hematological indices in sickle cell trait (SCT) carriers compared to control subjects, suggesting an involvement of MCT-1 in hemorheological disturbances in SCT carriers.
EA 3596, Laboratoire ACTES, Université des Antilles et de la Guyane, Campus de Fouillole, 97159 Pointe-à-Pitre, Guadeloupe. pconnes@yahoo.fr
Copyright© 2007 by The Physiological Society of Japan