Hemodynamics under Hippocampal Functional Hyperemia in Anesthetized Rat: A Greater Contribution of Red Blood Cell Velocity Compared to Its Concentration
Jpn J Physiol Vol.55, No.5 pp.303-307
Abstract: It remains controversial which of the two regulators, red blood cell velocity (RBC-V) or concentration (RBC-C), is a main contributor to increasing flow (RBC-F) during functional hyperemia in the rat hippocampus induced by N-methyl-D-aspartate (NMDA). To address this, we monitored these parameters simultaneously under NMDA-infusion via microdialysis in the hippocampus of urethane-anesthetized rats and found a greater elevation in RBC-V than in RBC-C. This suggests that an RBC-V-dependent increase in RBC-F occurs under NMDA-induced functional hyperemia in the hippocampus as well as in the cortex.
Laboratory of Exercise Biochemistry, University of Tsukuba Graduate School of Comprehensive Human Sciences, 1-1-1 Tennôdai, Tsukuba, 305-8574 Japan. hsoya@taiiku.tsukuba.ac.jp
Copyright© 2007 by The Physiological Society of Japan