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Vasodilatation of the Hindquarters Induced by Antagonism of GABAA Receptors in the Freely Moving Rat

Jpn J Physiol Vol.55, No.1 pp.75-78
Yumi Takemoto
Abstract: An intracisternal injection of the GABAA receptor antagonist bicuculline into conscious rats increased arterial pressure and decreased hindquarter resistance. Propranolol attenuated only the resistance response, but ganglionic block abolished both responses. These findings suggest that central GABAA receptor blockade induces an autonomic pressor action with hindquarter vasodilatation.

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Department of Neurophysiology, Division of Integrated Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University, Minami-ku, Hiroshima, 734-8551 Japan. yumitake@hiroshima-u.ac.jp
Copyright© 2007 by The Physiological Society of Japan