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Effects of Hydrogen Peroxide on Contraction of Skinned Aorta from Guinea Pigs

Jpn J Physiol Vol.53, No.6 pp.471-474
Wataru Sakurai, Masaru Watanabe, Akira Yamashina, Masato Konishi
Abstract: We examined the effects of hydrogen peroxide (H2O2) on the contractile force of cell membrane permeabilized descending thoracic aorta from guinea pigs. H2O2 enhanced generated force in the Ca2+-induced contraction at any given concentration of Ca2+, and maintained force level in the 30 mM Mg2+-induced Ca2+-independent force maintenance. H2O2 seems to directly enhance the cross-bridge interaction of aortic smooth muscles.

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Second Department of Internal Medicine, Tokyo Medical University, Shinjuku-ku, Tokyo, 160-0023 Japan. celsior@vc.kcom.ne.jp
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