Possible Involvement of Apoptotic Death of Myocytes in Left Ventricular Remodeling after Myocardial Infarction
Jpn J Physiol Vol.53, No.3 pp.247-252
Abstract: Pathophysiological roles of apoptosis in post-infarction left ventricular (LV) remodeling have not been well characterized. This study showed that TUNEL- or cleaved caspase-3–positive myocytes were identified late after ligation of the left coronary artery in rats, suggesting that apoptotic myocyte death contributed to the morphological change associated with LV remodeling.
Laboratory of Biomedical Control, Research Institute for Electronic Science, Hokkaido University, Sapporo, 060-0812 Japan. kawahara@bmc.es.hokudai.ac.jp
Copyright© 2007 by The Physiological Society of Japan