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Two-Week, but Not 1-Week, Hypoxic Exposure Enhances Nitric Oxide-Mediated Basal Tone Regulation in Rat Resistance Pulmonary Arteries

Jpn J Physiol Vol.51, No.3 pp.395-398
M. Shirai, A. Shimouchi, S. Ikeda, H. Oya, K.-Y. Min, A. T. Kawaguchi, H. Mori, I. Ninomiya
Abstract: We measured internal diameter (ID) changes in resistance and conduit pulmonary arteries of 1- and 2-week hypoxic rats and normoxic control rats in response to nitric oxide synthase (NOS) inhibitors in vivo. At 2 weeks of hypoxic exposure, the ID reduction as a result of NOS inhibition was enhanced within the resistance arteries, but not at 1 week of hypoxia.

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National Cardiovascular Center Research Institute, Osaka, 565-8565 Japan. mshiraim@res.ncvc.go.jp
Copyright© 2007 by The Physiological Society of Japan